31 To explore the sources of heterogeneity among studies and

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pandora charms If the highest category of the studies was open ended, we considered the difference from the lowest range to the median to be equivalent to the same difference in the closest adjacent category. If fruit and vegetable consumption was reported by servings or times, we converted it into the standard serving for the dose response analysis, which was defined as 77 g for vegetables and 80 g for fruit.26In addition, we examined non linear associations between fruit and vegetable consumption and all cause mortality using a two stage random effects dose response meta analysis. This was done by modelling consumption with the use of restricted cubic splines with three knots at fixed centiles (10% https://www.charmspandora-canada.com/, 50%, and 90%) of the distribution.27 28 We first estimated a restricted cubic spline model with a generalised least squares regression, considering the correlation within each set of published hazard ratios.25 We then combined the study specific estimates, using the restricted maximum likelihood method in a multivariate random effects meta analysis.22 We estimated the pooled hazard ratios for servings of fruit and vegetables a day using a procedure to tabulate and plot results.29 A test for a non linear relation was calculated by making the coefficient of the second spline equal to zero.We evaluated heterogeneity between studies with Cochran’s Q test (P30 and used I2 to quantify the proportion of the total variation due to that heterogeneity.31 To explore the sources of heterogeneity among studies and test the robustness of the associations, we conducted subgroup analyses and several sensitivity analyses. pandora charms

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